Schizophrenia: susceptibility genes and oligodendroglial and myelin related abnormalities
نویسندگان
چکیده
منابع مشابه
Schizophrenia: susceptibility genes and oligodendroglial and myelin related abnormalities
Given that the genetic risk for schizophrenia is highly polygenic and the effect sizes, even for rare or de novo events, are modest at best, it has been suggested that multiple biological pathways are likely to be involved in the etiopathogenesis of the disease. Most efforts in understanding the cellular basis of schizophrenia have followed a "neuron-centric" approach, focusing on alterations i...
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PSD-95 associated PSD proteins play a critical role in regulating the density and activity of glutamate receptors. Numerous previous studies have shown an association between the genes that encode these proteins and schizophrenia (SZ) and autism spectrum disorders (ASD), which share a substantial portion of genetic risks. We sequenced the protein-encoding regions of DLG1, DLG2, DLG4, DLGAP1, DL...
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INTRODUCTION Advances in genotyping, mapping and genome analysis methods over the last few years offer great promise towards the discovery of genes involved in the pathogenesis of schizophrenia, a mental disorder with a high degree of heritability. METHODS This article draws on published reports in major international journals in the field of schizophrenia and human genetics. RESULTS We sum...
متن کاملSearching for susceptibility genes in schizophrenia.
The existence of an important genetic contribution to the aetiology of schizophrenia is well established from genetic epidemiological studies. However, the mode of transmission is complex and non-Mendelian. The main approaches used to identify susceptibility genes are linkage and association studies and the study of cytogenetic abnormalities associated with or linked to schizophrenia. Many link...
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ژورنال
عنوان ژورنال: Frontiers in Cellular Neuroscience
سال: 2014
ISSN: 1662-5102
DOI: 10.3389/fncel.2014.00005